- Dr. Tricia Burdo, Temple University School of Medicine (https://medicine.temple.edu/tricia-burdo)
Monocyte/macrophage traffic and peripheral nerve pathogenesis
This project examines the role that monocytes and macrophages have in the development and progression of peripheral neuropathy associated with SIV infection. This is an important model for HIV peripheral neuropathy and the nonhuman primate model provides valuable information regarding the pathogenesis of this disease and opens various potential avenues for treatment.
Papers of interest:
- Lakritz JR, Robinson JA, Polydefkis MJ, Miller AD, Burdo T. Loss of intraepidermal nerve fiber density during SIV peripheral neuropathy is mediated by monocyte activation and elevated monocyte chemotactic proteins. J Neuroinflamm, 2015, 12(1):237.
- Burdo TH, Miller AD. Animal models of HIV peripheral neuropathy. Future Virol. 2014, 9(5):465-474.
- Burdo TH, Orzechowski K, Miller AD, Williams K. Dorsal root ganglia damage in SIV-infected rhesus macaques: An animal model of HIV-induced sensory neuropathy. Am J Pathol, 2012 180(4): 1362-1369.
- Dr. Ken Williams, Boston College (http://www.bc.edu/schools/cas/biology/facadmin/williams.html)
I provide pathology support for nonhuman primate SIV infection models and the role that monocytes/macrophages have in the development of cardiac disease.
- Walker JA, Beck GA, Campbell JH, Miller AD, Burdo TH, Williams KC. Anti-α4 integrin antibody blocks monocyte/macrophage traffic to the heart and decreases cardiac pathology in a SIV infection model of AIDS. J Am Heart Assoc, 2015, 4(7):e001932.
- Walker JA, Sulciner ML, Misgen KD, Miller AD, Burdo TH, Williams K. Elevated numbers of CD163+ macrophages in hearts of SIV infected monkeys correlates with cardiac pathology and fibrosis. AIDS Res Hum Retrovirsues 2014, 30(7): 685-694.
- Dr. Sharon Center, Cornell University College of Veterinary Medicine (http://www.vet.cornell.edu/faculty/Center/)
Dr. Center and Miller are collaborating on a genetic analysis of canine hepatocellular carcinoma.