The Miller laboratory is focused on studying the mechanisms underlying neurologic disease in companion animals utilizing naturally occurring disease. The lab focuses on using the dog as a natural disease model for human brain cancer, primarily meningioma and glioma. Certain dog breeds (Boxer, Boston terrier, French and English bulldog) develop gliomas at a high rate and compare favorably to their human counterparts. We use a variety of histologic, immunohistochemical, and molecular studies.
We are investigating the roles that novel gene mutations have in the genesis of canine meningioma. We are also studying the immune cell microenvironment in canine and feline brain tumors in order to determine if a relationship exists between immune cell infiltration and post-surgical outcome. The Miller laboratory is developing novel immunohistochemical markers for neoplasia in dogs and cats to better aid in diagnostic classification and design of prognostic studies.
Other research projects included characterizing novel causes of infectious and non-infectious neurologic disease in companion animals. The lab also provides experimental pathology support to a number of experimental animal models of infectious disease.